| Abstract
| - Activity-guided fractionation led to the isolation of luteolin (1) from the leaves of Sennasiamea (syn.Cassiasiamea). This compound was found to be an antagonist at the adenosine A1 receptor with a Kivalue in the low micromolar range. Four additional nonactive compounds (2−5) were also isolated, andtheir structures were elucidated. One compound was identified as cassia chromone (5-acetonyl-7-hydroxy-2-methylchromone) (2). Three other compounds are new, and they were identified as 5-acetonyl-7-hydroxy-2-hydroxymethyl-chromone (3), 4-(trans)-acetyl-3,6,8-trihydroxy-3-methyldihydronaphthalenone (4), and4-(cis)-acetyl-3,6,8-trihydroxy-3-methyldihydronaphthalenone (5).
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