| Abstract
| - The estrogenic activity of a series of analogues of the daucane ester ferutinin (1a) modified at the acylmoiety was investigated in a yeast screen containing the human estrogen receptor α. Rather strictstructure−activity relationships were observed. Thus, while the parent polyol (jaeschkeanadiol, 2a) wasinactive, the presence of a p-hydroxybenzoyl moiety was necessary for activity in the yeast screen.Homologation and vinylation were both detrimental for activity, as were methylation of the p-hydroxylsubstituent and the introduction of oxygen functions on the adjacent carbons.
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