| Abstract
| - Seven sesquiterpene lactones, (−) sivasinolide (1), a new naturally occurring eudesmanolide (altissin, 2),desacetyl-β-cyclopyrethrosin (3), tatridin-A (4), 1-epi-tatridin B (5), 1α,10β-epoxy-6-hydroxy-1,10H-inunolide (6), and spiciformin (7), were isolated from Anthemis altissima. Also isolated were 10 knownflavonoids, namely, apigenin (8), kaempferol 4‘-methyl ether (9), quercetin (10), quercetin 3-methyl ether(11), isorhamnetin (12), rhamnetin (13), 6-hydroxyquercetin 3,6,4‘-trimethyl ether (14), isoquercetrin (15),taxifolin (16), and eriodictyol (17), and one phenolic acid, chlorogenic acid (18). The structure and thestereochemistry of compound 2 were deduced by spectroscopic methods. The in vitro activity of thesesquiterpene lactones (1−5) against Helicobacter pylori, as well as against three Gram-positive andthree Gram-negative bacteria growing aerobically, was tested using the microdilution method. Compounds8−18 have also been tested against H. pylori.
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