| Abstract
| - The dried aerial parts of Euphorbia mongolica afforded three new acylated polyhydroxy diterpenoidsbased on the jatrophane framework. The structures were established by means of a combination of 1Dand 2D NMR techniques and mass spectrometry as (2S*,3S*,4R*,5R*,7S*,8R*,13S*,15R*)-5α,7β,8α-triacetoxy-3β-benzoyloxy-15β-hydroxyjatropha-6(17),11E-diene-9,14-dione (1), (2S*,3S*,4R*,5R*,7S*,8S*,9S*13S*,15R*)-5α,7β,8α,9α,15β-pentaacetoxy-3β-benzoyloxyjatropha-6(17),11E-dien-14-one (2), and(2S*,3S*,4R*,5R*,7S*,8S*,9S*13S*,15R*)-3β,7β,8α,9α,15β-pentaacetoxy-5α-benzoyloxyjatropha-6(17),11E-dien-14-one (3). When the isolates were assayed for multidrug resistance-reversing activity in arhodamine 123 exclusion test using L5178 mouse lymphoma cells, all compounds demonstrated aconcentration-dependent effect in inhibiting the efflux pump activity of these tumor cells in the range11.2−112 μM.
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