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À propos de : The Isolation and Structure Elucidation of Tasiamide B, a4-Amino-3-hydroxy-5-phenylpentanoic Acid Containing Peptide from the MarineCyanobacterium Symploca sp.        

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  • The Isolation and Structure Elucidation of Tasiamide B, a4-Amino-3-hydroxy-5-phenylpentanoic Acid Containing Peptide from the MarineCyanobacterium Symploca sp.
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  • A new cytotoxic peptide, which displayed an IC50 value of 0.8 μM against KB cells, has been isolatedfrom the marine cyanobacterium Symploca sp. The planar structure of tasiamide B (1), deduced by 2DNMR experiments, contains the unusual amino acid-derived residue 4-amino-3-hydroxy-5-phenylpentanoicacid (Ahppa). The configuration of 1 was deduced by HPLC analysis of degradation products.
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