| Abstract
| - The chemical investigation of the cytotoxic and antituberculosis active MeOH crude extract of the marinesponge Pachychalina sp. led to the isolation of six new nitrogenous metabolites, including ingenamine G(1), as well as a mixture of new cyclostellettamines G, H, I, K, and L (10−14) with the knowncyclostellettamines A−F (4−9). Structural assignments of compound 1 were based on the analysis of MSand NMR data, while the structures of compounds 10−14 could be established by HPLC-MS/MS analysis.Ingenamine G displayed cytotoxic activity against HCT-8 (colon), B16 (leukemia), and MCF-7 (breast)cancer cell lines, antibacterial activity against Staphylococcus aureus (ATCC 25923), Escherichia coli(ATCC 25922), and four oxacilin-resistant S. aureus strains, and antimycobacterial activity againstMycobacterium tuberculosis H37Rv.
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