| Abstract
| - Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophoraflavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeastand Ishikawa Var-I bioassays. Kurarinone showed weak estrogenic activity both in the yeast screen andin the Ishikawa Var-I assay with EC50 values of 4.6 and 1.66 μM, respectively. Furthermore, kurarinonewas found to have potent cytotoxic activity (IC50 value = 22.2 μM) against human MCF-7/6 breast cancercells in the sulforhodamine-B assay.
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