| Abstract
| - The Gulf of California shell-less mollusc Dolabella auricularia has been found to contain a new14-membered macrocyclic lactone linked to a 2,4-di-O-methyl-l-α-rhamnopyranoside, designated dolastatin19 (1). The new cancer cell growth inhibitor (1, 8.33 × 10-8% yield) was obtained by bioassay (P388lymphocytic leukemia and human cancer cell lines) directed isolation, accompanied by debromoaplysiatoxin(9.17 × 10-7% yield) and anhydrodebromoaplysiatoxin (2.0 × 10-7% yield). The structures were determinedon the basis of analyses of high-resolution mass spectra and high-field NMR data. All the relativestereochemistry for the chiral centers was designated by utilizing NMR techniques.
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