| Abstract
| - Investigations of a southern Australian marine sponge, Oceanapia sp., have yielded two new β methylbranched bisthiocyanates, thiocyanatins D1 (3a) and D2 (3b), along with two new thiocarbamatethiocyanates, thiocyanatins E1 (4a) and E2 (4b). The new thiocyanatins belong to a rare class of bioactivemarine metabolite previously only represented by thiocyanatins A−C (1, 2a/b). Structures were assignedon the basis of detailed spectroscopic analysis, with comparisons to the known bisthiocyanate thiocyanatinA (1) and synthetic model compounds (5−7). The thiocyanatins exhibit potent nematocidal activity, andpreliminary structure−activity relationship investigations have confirmed key characteristics of thethiocyanatin pharmacophore.
|
