| Abstract
| - Fifteen stilbenoids and two alkaloids from Stemona collinsae, S. tuberosa, and S. peirrei were testedalongside the commercially available stilbenoids resveratrol and pinosylvin for inhibition of leukotrieneformation in an ex vivo test system based on activated human neutrophilic granulocytes. The stilbenoidsresveratrol (1), pinosylvin (2), dihydropinosylvin (3), stilbostemin A (4), stilbostemin B (5), stilbosteminD (6), stilbostemin F (7), stilbostemin G (8), stemofuran B (9), stemofuran C (10), stemofuran D (11),stemofuran G (12), stemofuran J (13), stemanthrene A (14), stemanthrene B (15), stemanthrene C (16),and stemanthrene D (17) showed structure-dependent activities with IC50 values ranging from 3.7 to>50 μM. The alkaloids tuberostemonine (18) and neotuberostemonine (19) were inactive at a concentrationof 50 μM.
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