| Abstract
| - Four new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotectiveactivity-guided isolation and were characterized as decursinol derivatives 4‘ ‘-hydroxytigloyldecursinol(1), 4‘ ‘-hydroxydecursin (2), (2‘ ‘S,3‘ ‘S)-epoxyangeloyldecursinol (3), and (2‘ ‘R,3‘ ‘R)-epoxyangeloyldecursinol(4), respectively. All four new dihydropyranocoumarins and major coumarin derivatives of A. gigas,decursinol and decursin, exhibited signficant protective activity against glutamate-induced neurotoxicitywhen added to primary cultures of rat cortical cells at concentrations ranging from 0.1 to 10 μM.
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