| Abstract
| - The new glycoresins, ipomoeassins A−E (1−5), have been isolated from the leaves of Ipomoea squamosa.The structures were elucidated by spectroscopic analyses and chemical transformations. The absoluteconfigurations of C-5 (ipomoeassins 3−5) and C-11 (ipomoeassins 1 and 2) were determined by theirderivatives with (R)- and (S)-MPA. All the isolates were active in the A2780 human ovarian cancer cellline assay, and 4 showed the highest activity with an IC50 value of 35 nM.
|
