| Abstract
| - Serotonin receptor (5-HT7) binding assay-directed fractionation of a methanol extract of the dried roots of Angelicasinensis led to the isolation and identification of 21 compounds including a new phenolic ester, angeliferulate (1), andthree new phthalides, 10-angeloylbutylphthalide (2), sinaspirolide (3), and ansaspirolide (4), along with 17 knowncompounds, p-hydroxyphenethyl trans-ferulate (5), Z-ligustilide (6), Z-butylidenephthalide (7), senkyunolide I (8), Z-6-hydroxy-7-methoxydihydroligustilide (9), N-butylbenzenesulfonamide (10), 11(S),16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1-yl acetate (11), (3R,8S)-falcarindiol (12), heptadeca-1-en-9,10-epoxy-4,6-diyne-3,8-diol (13), oplopandiol(14), 8-hydroxy-1-methoxy-, Z-9-heptadecene-4,6-diyn-3-one (15), imperatorin, ferulic acid, vanillin, stigmasterol, sucrose,and 1,3-dilinolenin. This is the first report of a sulfonamide (10) identified from a higher plant source, although itspresence needs further investigation. Biosynthetic pathways for dimeric phthalides 3 and 4 are proposed. Compounds5, 7, 11, 12, 15, and imperatorin exhibited affinity toward 5-HT7 receptors in a competitive binding assay.
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