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À propos de : Cinnafragrins A−C, Dimeric and Trimeric Drimane Sesquiterpenoids from Cinnamosmafragrans, and Structure Revision of Capsicodendrin        

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  • Cinnafragrins A−C, Dimeric and Trimeric Drimane Sesquiterpenoids from Cinnamosmafragrans, and Structure Revision of Capsicodendrin
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  • Two new dimeric sesquiterpenoids and a new trimeric drimane sesquiterpenoid named cinnafragrins A−C (1−3), togetherwith cinnamodial (4), d-mannitol, capsicodendrin (5), and a vitamin E analogue, δ-tocotrienol, were isolated fromCinnamosma fragrans, a Malagasy medicinal plant. The structures of the new compounds were determined on the basisof physical, chemical, and spectroscopic evidence. Capsicodendrin, previously isolated from Capsicodendron dinisiiand tentatively suggested to be a tetramer of cinnamodial, was revised structurally as a mixture of C-12‘-epimers of12‘-hydroxycinnafragrin B by extensive 2D NMR analysis and X-ray crystallography of the lactone derivative,cinnafragrolide (6). The chemosystematics of the family Canellaceae are discussed.
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