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À propos de : Hypoxia-Selective Antitumor Agents: Norsesterterpene Peroxides from the Marine SpongeDiacarnus levii Preferentially Suppress the Growth of Tumor Cells under Hypoxic Conditions        

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  • Hypoxia-Selective Antitumor Agents: Norsesterterpene Peroxides from the Marine SpongeDiacarnus levii Preferentially Suppress the Growth of Tumor Cells under Hypoxic Conditions
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  • As part of an ongoing research program to discover natural products that suppress the hypoxia-activated tumor survivalpathways, the lipid extract of the Papua New Guinea marine sponge Diacarnus levii was found to suppress hypoxia-induced HIF-1 activation and hypoxic tumor cell survival. Bioassay-guided isolation of D. levii yielded four newnorsesterterpene peroxides, diacarnoxides A−D. Diacarnoxide B exhibits a significantly enhanced ability to suppressthe growth of tumor cells under hypoxic conditions.
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