| Abstract
| - Induction of the production of emericellamides A and B (1, 2), by the marine-derived fungus Emericella sp., wasobserved during co-culture with the marine actinomycete Salinispora arenicola. The planar structures of these newcyclic depsipeptides, which incorporate 3-hydroxy-2,4-dimethyldecanoic acid and 3-hydroxy-2,4,6-trimethyldodecanoicacid, were assigned by combined chemical and spectral methods. The absolute configurations of the amino acids, andthose of the chiral centers on the side chain, were established by application of the Marfey's method, by J-basedconfiguration analysis, and by application of the modified Mosher method. Emericellamides A and B show modestantibacterial activities against methicillin-resistant Staphylococcus aureus with MIC values of 3.8 and 6.0 μM, respectively.
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