| Abstract
| - Four bis-piperidine alkaloids, madangamine F (1), haliclonacyclamine F (2). and arenosclerins D (3) and E (4), havebeen isolated from the marine sponge Pachychalina alcaloidifera and have been identified by analysis of spectroscopicdata. The alkaloids displayed cytotoxic activity against different cancer cell lines. These results support the hypothesisof a common biogenetic origin for the Haplosclerida bis-piperidine and bis-pyridine alkaloids.
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