| Abstract
| - Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendron sp. led to theisolation of two new cardenolides, elaeodendrosides T and U (1 and 2). The structures of the new compounds wereelucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 3, 4, and 5 showed significantantiproliferative activity against A2780 human ovarian cancer cells with IC50 values of 0.085, 0.019, 0.19, and 0.10μM, respectively, while compounds 2 and 6 were less active.
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