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À propos de : Polydiscamides B−D from a Marine Sponge Ircinia sp. as Potent Human Sensory Neuron-Specific G Protein Coupled Receptor Agonists        

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  • Polydiscamides B−D from a Marine Sponge Ircinia sp. as Potent Human Sensory Neuron-Specific G Protein Coupled Receptor Agonists
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  • Polydiscamides B, C, and D (1−3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.
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  • Polydiscamides B−D from a Marine Sponge Ircinia sp.
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