| Abstract
| - A methanol extract of the dried bark of Liriosma ovata afforded two new isoprenoid glycosides, a eudesmane sesquiterpene, 1α(β-d-glucopyranosyloxy)eudesma-3α,4β, 11-triol (1), and a C13-norisoprenoid, 3α,6α-dihydroxymegastigman-7-en-9-one 3-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (2), as well as a known constituent, isopropyl-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (3). The structures of 1 and 2 were determined using spectroscopic methods. The methanol extract had a significant topical anti-inflammatory activity (ID50, dose inducing 50% edema inhibition = 780 µg/cm2) about 8 times less than that of indomethacin (ID50, 93 µg/cm2) assayed by the croton oil ear test in mice. In addition, the chloroform extract and compounds 1 and 2 showed weak antimicrobial activity against Staphylococcus aureus (MIC = 5.1, 2.1, and 4.0 mg/mL, respectively) using a broth microdilution assay.
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