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À propos de : Asymmetric Reductive Cyclization. Total Synthesis of(−)-C10-Desmethyl Arteannuin B        

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  • Asymmetric Reductive Cyclization. Total Synthesis of(−)-C10-Desmethyl Arteannuin B
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  • An efficient total synthesis of(−)-C10-desmethyl arteannuin B (5) has beenachieved. The sequencefeatures the use of a chiral auxiliary to introduce absolute asymmetryat an early stage and astereoselective, chelation-controlled reductive cyclization of8, using samarium diiodide as thereducing agent. The methodology promises to be applicable to thesynthesis of a wide range ofanalogs capable of being converted to potent antimalarial agentsrelated to artemisinin (1).
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