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| - Isolation and Stereostructures of Dolastatin G and NordolastatinG, Cytotoxic 35-Membered Cyclodepsipeptides from the JapaneseSea Hare Dolabella auricularia
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| - A bioassay-directed fractionation of the cytotoxicconstituents of the Japanese sea hare Dolabellaauricularia resulted in the isolation of two 35-membereddepsipeptides dolastatin G (1) andnordolastatin G (2), which showed cytotoxicity against HeLaS3 cells with IC50 values of 1.0and5.3 μg/mL, respectively. The gross structures of thesesubstances were established by spectroscopicanalysis including 2D NMR techniques. The absolute stereostructureof 1 was determined by chiralHPLC analysis of amino acid components obtained from acid hydrolysis of1 and by theenantioselective syntheses of two degradation products arising frompolyketide portions. Nordolastatin G (2) is a congener that has the same absolutestereochemistry as that of 1.
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