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  • An Approach to Photolabile, Fluorescent Protecting Groups
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  • The photolabile and fluorescent system 1 was preparedvia a convergent route which involvedthymidine 3‘-functionalized with a proline residue.Photodecomposition of 1 was examined using360 nm irradiation. Without any additives, 5‘-silylated thymidinewas not formed, but the Nα-deprotected cyclization precursor II accumulated instead.However, in the presence of ethanolamine,5‘-silylated thymidine formed at a rate which increases with theconcentration of ethanolamine.
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