Documentation scienceplus.abes.fr version Bêta

À propos de : Building Units for N-Backbone Cyclic Peptides. 3. Synthesis ofProtected Nα-(ω-Aminoalkyl)amino Acids andNα-(ω-Carboxyalkyl)amino Acids        

AttributsValeurs
type
Is Part Of
Subject
Title
  • Building Units for N-Backbone Cyclic Peptides. 3. Synthesis ofProtected Nα-(ω-Aminoalkyl)amino Acids andNα-(ω-Carboxyalkyl)amino Acids
has manifestation of work
related by
Author
Abstract
  • An improved synthesis of a family of amino acids thatcontain ω-aminoalkyl groups and of a newfamily containing ω-carboxyalkyl groups linked to the α-amine isdescribed. The synthesis wasperformed by alkylation of suitably monoprotected alkylenediamines andprotected ω-amino acidswith triflates of α-hydroxy acid esters. The reaction proceededwith inversion of configurationyielding optically pure products. TheNα-(ω-aminoalkyl)amino acids andNα-(ω-carboxyalkyl)aminoacids were orthogonally protected to allow their incorporation intopeptides by solid-phase peptidesynthesis (SPPS) methodology.
article type
is part of this journal



Alternative Linked Data Documents: ODE     Content Formats:       RDF       ODATA       Microdata