| Abstract
| - A total synthesis of (+)-quassin from naturally occurring (S)-(+)-carvone is described. The totalnumber of steps was 28, and the overall yield was about 2.6%. The synthetic strategy for theconstruction of the tetracyclic carbon framework was based on a C→ABC→ABCD ring annulationsequence, involving an aldol reaction, an intramolecular Diels−Alder reaction, and an intramolecularacylation as the key steps. Subsequent functionalization of ring A and ring C then afforded thetarget (+)-quassin.
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