| Abstract
| - Efficient 1,4-asymmetric induction has been achieved in the highly stereocontrolled intramolecular[2 + 2] cycloadditions between ketenimines and imines, leading to 1,2-dihydroazeto[2,1-b]quinazolines. The chiral methine carbon adjacent to the iminic nitrogen controls the exclusiveformation of the cycloadducts with relative trans configuration at C2 and C8. The stepwisemechanistic model, based on theoretical calculations, fully supports the stereochemical outcome ofthese cycloadditions.
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