Documentation scienceplus.abes.fr version Bêta

À propos de : Design and Synthesis of a Conformationally Restricted TransPeptide Isostere Based on the Bioactive Conformations ofSaquinavir and Nelfinavir        

AttributsValeurs
type
Is Part Of
Subject
Title
  • Design and Synthesis of a Conformationally Restricted TransPeptide Isostere Based on the Bioactive Conformations ofSaquinavir and Nelfinavir
has manifestation of work
related by
Author
Abstract
  • The design and synthesis of a new peptide isostere which contains a trans alkene core is described.The key step involves a Wadsworth−Emmons reaction between chiral aldehyde (2S)-9a and chiralphosphonate 7 under base-sensitive conditions to give a chiral enone (2R)-24a which was reducedto afford the desired trans alkene isosteres (2R,5R)-6a and (2R,5S)-6b (Scheme ). A potentialapplication of this isostere in the synthesis of HIV protease inhibitors is also discussed.
article type
is part of this journal



Alternative Linked Data Documents: ODE     Content Formats:       RDF       ODATA       Microdata