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À propos de : Azadepsipeptides: Synthesis and Evaluation of a Novel Class ofPeptidomimetics        

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  • Azadepsipeptides: Synthesis and Evaluation of a Novel Class ofPeptidomimetics
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  • A general route to azadepsipeptides, a new class of pseudopeptides, has been established. Themethodology was applied to the synthesis of a bis-aza analogue of the antiparasitic cyclooctadepsipeptide PF1022A. Comparison of the X-ray crystal structures of natural PF1022A (8) and thechimeric aza analogue 9 revealed that the introduction of nitrogen in the backbone of PF1022Aresults in almost complete conservation of the 3D structure with only minor deviations at the newnitrogen positions.
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