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À propos de : Azomethine Ylide Cycloaddition/Reductive HeterocyclizationApproach to Oxindole Alkaloids: Asymmetric Synthesis of(−)-Horsfiline        

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  • Azomethine Ylide Cycloaddition/Reductive HeterocyclizationApproach to Oxindole Alkaloids: Asymmetric Synthesis of(−)-Horsfiline
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  • The intermolecular [3 + 2] annulation of azomethine ylides with 2(2-nitrophenyl)acrylate dienophilesfollowed by reductive heterocyclization affords the spiro(indole-pyrrolidine) ring system. Hence,this enable us to accomplish a concise and highly enantioselective synthesis of (−)-horsfiline 1,based on chiral auxiliary-directed π-face discrimination in the 1,3-dipolar cycloaddition of (1S,2R)-2-phenyl-1-cyclohexyl ester 4f with N-methylazomethine ylide.
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