| Abstract
| - A method for the synthesis of derivatives of the lead structures euniolide (1), 12,13-bisepieupalmerin(2), and eupalmerin acetate (3) containing tetrahydrofuran and tetrahydropyran ring systems wasdeveloped on the basis of alkali-induced intramolecular oxacyclizations. Representatives of the newanalogues were submitted to the in vitro antitumor cell-line-screening program of the NationalCancer Institute (NCI). While it was shown that a variety of structural modifications are possible,these transformations led typically to nontoxic synthetic cembranoids.
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