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À propos de : Antineoplastic Agents. 450. Synthesis of (+)-Pancratistatin from(+)-Narciclasine as Relay1a        

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  • Antineoplastic Agents. 450. Synthesis of (+)-Pancratistatin from(+)-Narciclasine as Relay1a
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  • (+)-Narciclasine (2) available in quantity from certain Amaryllidaceae species or by total synthesiswas employed as a precursor for a 10-step synthetic conversion (3.6% overall yield) to natural (+)-pancratistatin (1a). The key procedures involved epoxidation of natural (+)-narciclasine (2) toepoxide 6, reduction to diol 8, and formation of cyclic sulfate 12 and its ring opening with cesiumbenzoate followed by saponification of the benzoate to afford (+)-pancratistatin (1a).
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