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À propos de : A Modular Approach for the Synthesis of OligosaccharideMimetics        

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  • A Modular Approach for the Synthesis of OligosaccharideMimetics
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  • To allow modular syntheses of oligosaccharide mimetics, the potentially trifunctional glycoside 7was synthesized and used as a scaffold for the successive attachment of further monosaccharidederivatives to lead to the di-, tri-, and tetrasaccharide mimetics 11, 13, and 16. This syntheticstrategy can also be used to prepare oligovalent neoglycoconjugates, e.g., 18, which contains ninemannosyl units. The applied concept implies numerous options for the synthesis of a wide array ofstructural variations, biolabeling, or solid-phase synthesis as well as combinatorial approaches.
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