| Abstract
| - A new class of shape-modified nucleosides is introduced. These novel “fleximers” feature the purinering systems of adenosine, inosine, and guanosine split into their individual imidazole andpyrimidine components (as in 1−3). This structural modification serves to introduce flexibility intothe nucleoside while still retaining the elements essential for recognition. As a consequence, thesenovel fleximers should find use as bioprobes for investigating enzyme−coenzyme binding sites aswell as nucleic acid and protein interactions. Their design and synthesis are described.
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