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À propos de : Efficient Synthesis of IPL576,092: A NovelAnti-Asthma Agent        

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  • Efficient Synthesis of IPL576,092: A NovelAnti-Asthma Agent
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  • An enantioseletive synthesis of the novel anti-asthma agent IRL576,092 (2) is described. The syntheticroute developed involves stereoselective 1,2-reduction of theenone carbonyl functionality of 6 and subsequent hydroboration as the key steps. Starting from the commerciallyavailable 5-androsten-3β-ol-17-one 3, this approach affordsIPL576,092 (2) in nine steps with overall yields of 25%,employing a limited number of chromatographic steps.
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