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À propos de : General Approach for the StereocontrolledConstruction of the β-Lactam Ring inAmino Acid-Derived4-Alkyl-4-carboxy-2-azetidinones        

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  • General Approach for the StereocontrolledConstruction of the β-Lactam Ring inAmino Acid-Derived4-Alkyl-4-carboxy-2-azetidinones
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  • The first general approach toward the asymmetric synthesis of 4-alkyl-4-carboxy-2-azetidinones derivedfrom amino acids is described. The stereoselective construction of the β-lactam ring was achieved through base-mediated intramolecular cyclization of the correspondingNα-chloroacetyl derivatives bearing (+)- or (−)-10-(N,N-dicyclohexylsulfamoyl)isoborneol as chiral auxiliary (ee upto 82%).
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