About: Ti(II)-Mediated Conversion ofα-Heterosubstituted (O, N, S) Nitriles toFunctionalized Cyclopropylamines. Effectof Chelation on the Cyclopropanation Step

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Attributs	Valeurs
type	work Article
Is Part Of	http://hub.abes.fr/acs/periodical/joceah/2002/volume_67/issue_11/w
Subject	Note
Title	Ti(II)-Mediated Conversion ofα-Heterosubstituted (O, N, S) Nitriles toFunctionalized Cyclopropylamines. Effectof Chelation on the Cyclopropanation Step
has manifestation of work	http://hub.abes.fr/acs/periodical/joceah/2002/volume_67/issue_11/101021jo025634y/m/web http://hub.abes.fr/acs/periodical/joceah/2002/volume_67/issue_11/101021jo025634y/m/print
related by	http://hub.abes.fr/acs/periodical/joceah/2002/volume_67/issue_11/101021jo025634y/authorship/2 http://hub.abes.fr/acs/periodical/joceah/2002/volume_67/issue_11/101021jo025634y/authorship/1
Author	Szymoniak Jan Bertus Philippe
Abstract	α-Alkoxy, amino-, and thio nitriles undergo a Ti(II)-mediated coupling with Grignard reagents to affordheterofunctionalized cyclopropylamines. A chelation effectappears to be generally responsible for the spontaneouscontraction of the intermediate azatitanacycle leading tocyclopropane. By using the described reaction, 1-aminocyclopropanecarboxylic acids were prepared in four steps,in good overall yields, from the readily available benzyloxyacetonitrile.
article type	brief-report
is part of this journal	The Journal of Organic Chemistry

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