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À propos de : Incorporation of Ahc into Model Dipeptides as an Inducer of aβ-Turn with a Distorted Amide Bond. Conformational Analysis        

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  • Incorporation of Ahc into Model Dipeptides as an Inducer of aβ-Turn with a Distorted Amide Bond. Conformational Analysis
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  • The proline residue of dipeptides Ser-Pro and Pro-Ser has been replaced by 7-azabicyclo[2.2.1]heptane-1-carboxylic acid (Ahc), a conformationally restricted analogue of proline that is capableof mimicking distorted amides. The conformational analysis of the new peptides in the solid staterevealed that the Ahc-Ser sequence displays a type I β-turn, which includes a distorted amidebond. In contrast, the Ser-Ahc sequence exists in a nonfolded structure.
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