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À propos de : Synthesis of Cyclic Peptidomimetics fromAldol Building Blocks        

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  • Synthesis of Cyclic Peptidomimetics fromAldol Building Blocks
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  • Aldol products (3-hydroxy acids) with an allyl-protected hydroxy group were converted to amino alcoholsby Curtius rearrangement. Combination of the carboxylicacid with the amino alcohols gave the amides 10. Ring-closing metathesis led to the 12-membered lactams 12 asmixtures of E/Z-isomers. The scheme was also transferredto the solid-phase. In this case the macrolactams are formedvia cyclorelease. For a pair of E/Z-isomers the solutionconformation was determined by ROESY spectroscopy.
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