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À propos de : Reagent for Synthesis of Secondary Aminesby Two Consecutive N-Alkylations and ItsApplication to Orthogonally ProtectedSpermidine        

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  • Reagent for Synthesis of Secondary Aminesby Two Consecutive N-Alkylations and ItsApplication to Orthogonally ProtectedSpermidine
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  • A novel reagent, tert-butyl 2-naphthalenesulfonylcarbamate, has been designed to allow the stepwisesynthesis of secondary aliphatic amines by two consecutiveN-alkylations with intermediate Boc-cleavage and finaldesulfonylation under mild and experimentally convenientconditions. Its application was demonstrated to make anorthogonally protected spermidine derivative, suitable forfurther selective modification. Each individual step, including the final cleavage of 2-naphthalenesulfonyl to providethe secondary amine nitrogen, took place in high yield.
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