| Abstract
| - Six new macrolides, amphidinolides H2 (5), H3 (6), H4 (7), H5 (8), G2 (9), and G3 (10), have beenisolated from a marine dinoflagellate Amphidinium sp. (strain Y-42). Cytotoxicity of five derivatives(11−15) of amphidinolide H (1) in addition to 10 amphidinolides (1−10) containing amphidinolidesH (1), G (2), B (3), and D (4) was examined, and it was found that the presence of an allyl epoxide,an S-cis-diene moiety, and the ketone at C-20 was important for the cytotoxicity of amphidinolideH (1)-type macrolides.
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