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À propos de : Synthesis of Unsymmetrical Aroyl AcylImides by Aminocarbonylation of ArylBromides        

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  • Synthesis of Unsymmetrical Aroyl AcylImides by Aminocarbonylation of ArylBromides
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  • Aroyl imides were prepared by a palladium-catalyzed aminocarbonylation reaction of aryl bromides withcarbon monoxide and primary amides in good yields (58−72%). The reactions were carried out under mild conditions(5 bar, 120 °C) using 1 mol % of a palladium phosphinecomplex. Several aryl bromides were reacted with formamide, acetamide, benzamide, and benzenesulfonamide, respectively. For activated aryl bromides, a phosphine-to-palladium ratio of 2:1 was sufficient, but less reactive arylbromides required a ligand-to-palladium ratio of 6:1 in orderto stabilize the catalyst and achieve full conversion. Theimides were very sensitive to aqueous basic conditions andwere easily converted to aroyl amides or benzoic acids.
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