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À propos de : Synthesis of β- and γ-Carbolines by the Palladium/Copper-Catalyzed Coupling and Cyclization of TerminalAcetylenes        

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  • Synthesis of β- and γ-Carbolines by the Palladium/Copper-Catalyzed Coupling and Cyclization of TerminalAcetylenes
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  • A variety of 3-substituted β- and γ-carbolines have been synthesized from N-substituted 3-iodoindole-2-carboxaldehydes and 2-bromoindole-3-carboxaldehydes, respectively. The coupling of thesealdehydes with various terminal acetylenes with PdCl2(PPh3)2/CuI as the catalyst readily affordsthe corresponding alkynylindole carboxaldehydes, which have subsequently been converted to thecorresponding tert-butylimines and cyclized to β- and γ-carbolines by either copper-catalyzed orthermal processes.
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