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| - Synthesis of 3-Substituted 4-Aroylisoquinolines via Pd-CatalyzedCarbonylative Cyclization of 2-(1-Alkynyl)benzaldimines
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| - A number of 3-substituted 4-aroylisoquinolines have been prepared in good yields by treating N-tert-butyl-2-(1-alkynyl)benzaldimines with aryl halides in the presence of CO and a palladium catalyst.Synthetically the methodology provides a simple and convenient route to isoquinolines containingan aryl, alkyl, or vinylic group at C-3 and an aroyl group at C-4 of the isoquinoline ring. The reactionis believed to proceed via cyclization of the alkyne containing a proximate nucleophilic centerpromoted by an acylpalladium complex.
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