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À propos de : Alkynyliodonium Salts in Organic Synthesis. Development of aUnified Strategy for the Syntheses of (−)-Agelastatin A and(−)-Agelastatin B        

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  • Alkynyliodonium Salts in Organic Synthesis. Development of aUnified Strategy for the Syntheses of (−)-Agelastatin A and(−)-Agelastatin B
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  • The total syntheses of natural agelastatin A and agelastatin B were accomplished via a strategythat utilized an alkynyliodonium salt → alkylidenecarbene → cyclopentene transformation to converta relatively simple amino alcohol derivative to the functionalized core of the agelastatin system.Subsequent manipulations delivered debromoagelastatin, which served as a precursor to bothagelastatin A and agelastatin B. Alkylidenecarbene insertion chemoselectivity issues were exploreden route to the final targets.
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