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  • Asymmetric Synthesis of Polyhydroxy α-Amino Acids with theSulfinimine-Mediated Asymmetric Strecker Reaction: 2-Amino2-Deoxy l-Xylono-1,5-lactone (Polyoxamic Acid Lactone)
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  • Polyhydroxylated sulfinimines derived from protected 1,2-O-isopropyliden-l-threoses undergo thesulfinimine-mediated Strecker syntheses to give α-amino nitriles in good yield and de. A doublestereodifferentiation effect was not observed and the diastereoselectivity is controlled by the absoluteconfiguration of the sulfinyl group. Hydrolysis of the amino nitriles afforded the lactone ratherthan polyoxamic acid.
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