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À propos de : Synthesis of Small Cyclic Peptides viaReverse Turn Induced Ring ClosingMetathesis of Tripeptides        

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  • Synthesis of Small Cyclic Peptides viaReverse Turn Induced Ring ClosingMetathesis of Tripeptides
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  • A reverse turn induced (γ/β-turn) cyclization oftripeptides 1 can be performed in a ring closing metathesisreaction with Grubbs' catalyst to the corresponding cyclicpeptides 2. These cyclic peptides may be useful probes as aconformationally constrained mimic of the bioactive conformation of structurally related HIV protease inhibitors.
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