| Title
| - Novel Routes to 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazines and5,6,9,10,11,11a-Hexahydro-8H-pyrido[1,2-a]pyrrolo[2,1-c]pyrazines
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| Abstract
| - Condensation reactions of benzotriazole and 2-(pyrrol-1-yl)-1-ethylamine (1) with formaldehydeand glutaric dialdehyde, respectively, afforded intermediates 2 and 6. Subsequent nucleophilicsubstitutions of the benzotriazole group in 2 and 6 with Grignard reagents, sodium cyanide, andsodium borohydride gave 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines 3a−e, 4, 5 and 5,6,9,10,11,11a-hexahydro-8H-pyrido[1,2-a]pyrrolo[2,1-c]pyrazines 7a−c, 8, 9, respectively, in good yields.
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