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À propos de : Tandem Enantioselective Conjugate Addition−Cyclopropanation.Application to Natural Products Synthesis        

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  • Tandem Enantioselective Conjugate Addition−Cyclopropanation.Application to Natural Products Synthesis
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  • A tandem asymmetric conjugate addition−cyclopropanation was developed, in which a cyclic orlinear enone was converted to a TMS-protected 3-substituted-cyclopropanol in an efficient one-potreaction. These compounds were then selectively cleaved to yield α-methyl-β-alkyl ketones,α-methylene-enones, or chain extended γ-alkyl-enones. This methodology was applied to the formaltotal synthesis of (−)-(S,S)-clavukerin A and (+)-(R,S)-isoclavukerin.
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