Abstract
| - A highly stereoselective asymmetric synthesis of (−)-sedamine and (−)-lobeline is described frombenzaldehyde in 16 and 17 steps with an overall yield of 20% and 14%, respectively. The keyintermediate syn-3,4-epoxyalcohol was prepared in a highly diastereomeric fashion (>99% ee, dr)and served as a common intermediate for both alkaloids.
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