Abstract
| - A multipathway process comprising severalenzyme- and metal-catalyzed reactions has been exploredfor the asymmetric transformations of acyloxyphenyl ketonesto optically active hydroxyphenyl alcohols in the ester forms.The process comprises nine component reactions in threepathways, all of which take place by the catalytic actions ofonly two catalysts, a lipase and a ruthenium complex. Thesynthetic reactions were carried out on 0.2−0.6 mmol scalesfor eight different substrates under an atmosphere ofhydrogen (1 atm) in toluene at 70 °C for 3 days. In mostcases, the yields were high (92−96%) and the optical puritieswere excellent (96−98% ee), This work thus has demonstrated that enzyme−metal multicatalysis has great potential as a new methodology for asymmetric transformations.
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